London Genomics · Explainers

Five short films.
The pipeline, the graph, the proof.

Roughly ten to fifteen seconds each. Press space to play, ← → to skip between films, drag the scrubber to seek.

The pipeline run

VCF in · 13 stages · ≤ 1s

The knowledge graph

KRAS G12D · 8 hops · verdict

Determinism

Same input → same hash

The NHS path

Earned scale · 4 phases

Why now

7% · 237k · £2.2B

01The pipeline runVCF → signed report

VCF in. Thirteen stages. Signed report out.

Air-gappable. Deterministic. From a raw genome to a hashed clinical report in under one second on commodity hardware.

● stage 01 / 13 cold cache · 0.547s · warm · 0.016s

02The knowledge graphKRAS G12D · pancreatic adenocarcinoma

A flat lookup misses this. The graph doesn't.

From a single variant, eight hops out, the platform flags four EGFR-targeted drugs as cross-resistant. The mutation sits downstream of where those drugs act, so the upstream traversal is the only way to surface the call.

● hop 01 / 08 49,565 nodes · 91,653 edges · 16-hop capable

03DeterminismSame input · same hash · always

Run it twice. Or a thousand times. Get the same hash.

Reproduce any past report from VCF + manifest. 1,200-run determinism soak: 100 repeats produced bit-identical replay hashes. Verifiable in CI.

● SHA-256 replay_hash · golden_hash · bundle_hash

04The NHS pathEarned scale · 24 – 30 months

Blinded re-analysis first. Multi-Trust framework last.

Designed for how the NHS actually adopts software. Zero patient impact at the start. Each phase earns the next gate.

● phase 00 / 04 DCB0129 · Class IIa SaMD · ISO 13485

05Why nowThe gap, in three numbers

The science is here. The decision layer isn't.

The NHS runs half a million genomic tests every year. The cohort exists. The biomarkers exist. The drugs exist. What's missing is the layer that turns a result into a safe, ranked treatment plan.

● the gap Sholl 2024 · Pirmohamed BMJ · Elliott / NHS BSA